in claiming that, based on what we know from current science, natural abiogenesis is or isn't possible.

And they describe two rational Christian preferences about future scientific research, hoping that science either will or won't be more successful in finding a way for life to begin naturally.

And there is a continuing search for ways to reduce the minimal complexity that would be required for a system with self-replication (with "genes first") or metabolism (if "metabolism first") or both.

All proposals for a transition from nonlife to life must cope with various "chicken and egg" problems.

For example, all modern life involves proteins and DNA, but the production of protein requires DNA, and the production of DNA requires protein, and both require RNA and more, operating in a complex coordinated system.

• In an interview with Stanley Miller in 1996 we see an optimistic description of abiogenesis science and its prospects for development, and Miller concludes with a different perspective (compared with Rana & Ross) on the relatively small community of research scientists who are focusing on the origin of life.

• Ian Musgrave criticizes math-based claims for The Improbability of Abiogenesis because, among other reasons, precise specificity is not essential for functionality, and a huge number of "chemistry experiments in nature" can occur simultaneously.

To avoid the need for a complex system with proteins plus DNA, some scientists have proposed that RNA (which combines the replicating ability of DNA and catalytic activity of proteins) was the key life-producing molecule in the earliest living cells.

A prebiotic RNA World is still a popular theory, but questions have arisen due to the difficulty of RNA synthesis in prebiotic conditions, and because RNA functionality (in catalytic activity and self-replicating ability) has not matched the initial optimistic hopes.Scientists usually propose a four-stage process of formation for the first life: 1A.formation of small organic molecules (amino acids, nucleic acid bases,…), 1B.Before looking at web-pages with proposals (and criticisms, as in claims for INTELLIGENT DESIGN) for various scientific theories about a natural origin of life, let's get a "big picture overview" of some problems and possible solutions: There are chemistry problems in Stages 1A and 1B, due to some energetically unfavorable reactions and unproductive competitive reactions.But the toughest problems are biological, in Stages 2A and 2B, because the simplest possible "living system" seems to require hundreds of components interacting in an organized way to achieve self-replication and energy production, and this organized complexity would have to occur before natural selection (which depends on self-replication) was available.that gradually transformed into a more sophisticated form, a living organism.